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Cellular FLICE-inhibitory protein: an attractive therapeutic target?
Cellular FLIP, also known as FLICE-inhibitory protein, has been identified as an inhibitor of apoptosis triggered by engagement of Death Receptor (DR) such as Fas or TRAIL. c-FLIP is recruited to DR signalling complexes, where it prevents caspase activation. Animal models indicated that c-FLIP plays...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Informa Healthcare
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2984612/ https://ncbi.nlm.nih.gov/pubmed/12885274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.7.4.559 |
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