Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites.

A variety of evidence indicates that activation of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) in nerve terminals leads to enhanced neurotransmitter release. Arachidonic acid and its 12-lipoxygenase metabolite, 12-hydroperoxyeicosatetraenoic acid (12-HPETE), have been suggested to ac...

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Hauptverfasser: Piomelli, D, Wang, J K, Sihra, T S, Nairn, A C, Czernik, A J, Greengard, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC298320/
https://ncbi.nlm.nih.gov/pubmed/2554319
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