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Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites.

A variety of evidence indicates that activation of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) in nerve terminals leads to enhanced neurotransmitter release. Arachidonic acid and its 12-lipoxygenase metabolite, 12-hydroperoxyeicosatetraenoic acid (12-HPETE), have been suggested to ac...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Piomelli, D, Wang, J K, Sihra, T S, Nairn, A C, Czernik, A J, Greengard, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298320/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2554319/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8550
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