Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone Pharmacophore

Botulinum neurotoxins (BoNTs), and in particular serotype A, are the most poisonous of known biological substances, and are responsible for the flaccid paralysis of the disease state botulism. Because of the extreme toxicity of these enzymes, BoNTs are considered highest priority biothreat agents. T...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Burnett, James C., Li, Bing, Pai, Ramdas, Cardinale, Steven C., Butler, Michelle M., Peet, Norton P., Moir, Donald, Bavari, Sina, Bowlin, Terry
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983112/
https://ncbi.nlm.nih.gov/pubmed/21103387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OAB.S7251
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi