Elastin Peptides Signaling Relies on Neuraminidase-1-Dependent Lactosylceramide Generation

The sialidase activity of neuraminidase-1 (Neu-1) is responsible for ERK 1/2 pathway activation following binding of elastin peptide on the elastin receptor complex. In this work, we demonstrate that the receptor and lipid rafts colocalize at the plasma membrane. We also show that the disruption of...

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Autori principali: Rusciani, Anthony, Duca, Laurent, Sartelet, Hervé, Chatron-Colliet, Aurore, Bobichon, Hélène, Ploton, Dominique, Le Naour, Richard, Blaise, Sébastien, Martiny, Laurent, Debelle, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982818/
https://ncbi.nlm.nih.gov/pubmed/21103358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014010
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