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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Crohn’s disease and ulcerative colitis are inflammatory bowel diseases with high prevalence in humans. Nlrp3 interacts with the adaptor protein ASC to activate caspase-1 in inflammasomes, protein complexes responsible for the maturation and secretion of IL-1β and IL-18. Decreased expression of the N...

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Sonraí Bibleagrafaíochta
Main Authors: Zaki, Hasan, Boyd, Kelli L., Kastan, Michael B., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982187/
https://ncbi.nlm.nih.gov/pubmed/20303296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.03.003
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