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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
Crohn’s disease and ulcerative colitis are inflammatory bowel diseases with high prevalence in humans. Nlrp3 interacts with the adaptor protein ASC to activate caspase-1 in inflammasomes, protein complexes responsible for the maturation and secretion of IL-1β and IL-18. Decreased expression of the N...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2982187/ https://ncbi.nlm.nih.gov/pubmed/20303296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.03.003 |
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