Abl Tyrosine Kinase Phosphorylates Nonmuscle Myosin Light Chain Kinase to Regulate Endothelial Barrier Function

Nonmuscle myosin light chain kinase (nmMLCK), a multi-functional cytoskeletal protein critical to vascular homeostasis, is highly regulated by tyrosine phosphorylation. We identified multiple novel c-Abl–mediated nmMLCK phosphorylation sites by mass spectroscopy analysis (including Y(231), Y(464), Y...

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Bibliographic Details
Main Authors: Dudek, Steven M., Chiang, Eddie T., Camp, Sara M., Guo, Yurong, Zhao, Jing, Brown, Mary E., Singleton, Patrick A., Wang, Lichun, Desai, Anjali, Arce, Fernando T., Lal, Ratnesh, Van Eyk, Jennifer E., Imam, Syed Z., Garcia, Joe G. N.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982111/
https://ncbi.nlm.nih.gov/pubmed/20861316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-10-0876
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