Abl Tyrosine Kinase Phosphorylates Nonmuscle Myosin Light Chain Kinase to Regulate Endothelial Barrier Function

Nonmuscle myosin light chain kinase (nmMLCK), a multi-functional cytoskeletal protein critical to vascular homeostasis, is highly regulated by tyrosine phosphorylation. We identified multiple novel c-Abl–mediated nmMLCK phosphorylation sites by mass spectroscopy analysis (including Y(231), Y(464), Y...

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Main Authors: Dudek, Steven M., Chiang, Eddie T., Camp, Sara M., Guo, Yurong, Zhao, Jing, Brown, Mary E., Singleton, Patrick A., Wang, Lichun, Desai, Anjali, Arce, Fernando T., Lal, Ratnesh, Van Eyk, Jennifer E., Imam, Syed Z., Garcia, Joe G. N.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982111/
https://ncbi.nlm.nih.gov/pubmed/20861316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-10-0876
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