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Dependency of γ-secretase complex activity on the structural state of bilayer
γ-secretase is a membrane protein complex associated with the production of Aβ peptides that are pathogenic in Alzheimer’s disease. We have characterized the activity of γ-secretase complexes under a variety of detergent solubilization and reconstitution conditions, and the structural state of prote...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981652/ https://ncbi.nlm.nih.gov/pubmed/20937251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.10.017 |
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