Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells

Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP). While enhanced expression of PTHrP is known to stimulate o...

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Detalhes bibliográficos
Main Authors: Ruppender, Nazanin S., Merkel, Alyssa R., Martin, T. John, Mundy, Gregory R., Sterling, Julie A., Guelcher, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981576/
https://ncbi.nlm.nih.gov/pubmed/21085597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015451
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