TGF-β promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling

Breast cancer frequently metastasizes to bone, where tumor cells receive signals from the bone marrow microenvironment. One relevant factor is TGF-β, which up regulates expression of the Hedgehog (Hh) signaling molecule Gli2 which in turn increases secretion of important osteolytic factors such as p...

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Bibliographic Details
Main Authors: Johnson, Rachelle W., Nguyen, Mai P., Padalecki, Susan S., Grubbs, Barry G., Merkel, Alyssa R., Oyajobi, Babatunde O., Matrisian, Lynn M., Mundy, Gregory R., Sterling, Julie A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077118/
https://ncbi.nlm.nih.gov/pubmed/21189326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2993
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