The Zinc Finger Transcription Factor Gli2 Mediates Bone Morphogenetic Protein 2 Expression in Osteoblasts in Response to Hedgehog Signaling

Bone morphogenetic protein 2 (BMP-2) plays a critical role in osteoblast function. In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2. Null mutation of the transcription factor Gli2, a mammalian homolog of Ci,...

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Main Authors: Zhao, Ming, Qiao, Mei, Harris, Stephen E., Chen, Di, Oyajobi, Babatunde O., Mundy, Gregory R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592805/
https://ncbi.nlm.nih.gov/pubmed/16880529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02214-05
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