Inhibition of Microtubule Assembly in Osteoblasts Stimulates Bone Morphogenetic Protein 2 Expression and Bone Formation through Transcription Factor Gli2

Bone morphogenetic protein 2 (BMP-2) is essential for postnatal bone formation and fracture repair. By screening chemical libraries for BMP-2 mimics using a cell-based assay, we identified inhibitors of microtubule assembly as stimulators of BMP-2 transcription. These microtubule inhibitors increase...

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Autori principali: Zhao, Ming, Ko, Seon-Yle, Liu, Jin-Hua, Chen, Di, Zhang, Jianghong, Wang, Baolin, Harris, Stephen E., Oyajobi, Babatunde O., Mundy, Gregory R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643819/
https://ncbi.nlm.nih.gov/pubmed/19103752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01566-08
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