Matrix Rigidity Regulates the Transition of Tumor Cells to a Bone-Destructive Phenotype through Integrin β3 and TGF-β Receptor Type II

Cancer patients frequently develop skeletal metastases that significantly impact quality of life. Since bone metastases remain incurable, a clearer understanding of molecular mechanisms regulating skeletal metastases is required to develop new therapeutics that block establishment of tumors in bone....

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Page, Jonathan M., Merkel, Alyssa R., Ruppender, Nazanin S., Guo, Ruijing, Dadwal, Ushashi C., Cannonier, Shellese, Basu, Sandip, Guelcher, Scott A., Sterling, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681301/
https://ncbi.nlm.nih.gov/pubmed/26115412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.06.026
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