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von Willebrand factor self-association on platelet GpIbα under hydrodynamic shear: effect on shear-induced platelet activation

The function of the mechanosensitive, multimeric blood protein von Willebrand factor (VWF) is dependent on its size. We tested the hypothesis that VWF may self-associate on the platelet glycoprotein Ibα (GpIbα) receptor under hydrodynamic shear. Consistent with this proposition, whereas Alexa-488–co...

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Autors principals: Dayananda, Kannayakanahalli M., Singh, Indrajeet, Mondal, Nandini, Neelamegham, Sriram
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981547/
https://ncbi.nlm.nih.gov/pubmed/20696943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269266
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