GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to...

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Detalhes bibliográficos
Main Authors: Lu, Ying-Jie, Leite, Luciana, Gonçalves, Viviane Maimoni, de Oliveira Dias, Waldely, Liberman, Celia, Fratelli, Fernando, Alderson, Mark, Tate, Andrea, Maisonneuve, Jean-François, Robertson, George, Graca, Rita, Sayeed, Sabina, Thompson, Claudette M., Anderson, Porter, Malley, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981440/
https://ncbi.nlm.nih.gov/pubmed/20858450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.09.031
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