Toll-like Receptor (TLR) 2 Mediates Inflammatory Responses to Oligomerized RrgA Pneumococcal Pilus Type 1 Protein

The pneumococcal type 1 pilus is an inflammatory and adherence-promoting structure associated with increased virulence in mouse models. We show that RrgA, an ancillary pilus subunit devoid of a lipidation motif, particularly when presented as part of an oligomer, is a TLR2 agonist. The surface-expos...

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Detalhes bibliográficos
Main Authors: Basset, Alan, Zhang, Fan, Benes, Cyril, Sayeed, Sabina, Herd, Muriel, Thompson, Claudette, Golenbock, Douglas T., Camilli, Andrew, Malley, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554933/
https://ncbi.nlm.nih.gov/pubmed/23233677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398875
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