Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA enhanced t...

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Detalhes bibliográficos
Main Authors: Orrskog, Sofia, Rounioja, Samuli, Spadafina, Tiziana, Gallotta, Marilena, Norman, Martin, Hentrich, Karina, Fälker, Stefan, Ygberg-Eriksson, Sofia, Hasenberg, Mike, Johansson, Björn, Uotila, Liisa M., Gahmberg, Carl G., Barocchi, Michèle, Gunzer, Matthias, Normark, Staffan, Henriques-Normark, Birgitta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531807/
https://ncbi.nlm.nih.gov/pubmed/23269830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00535-12
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