The Two Variants of the Streptococcus pneumoniae Pilus 1 RrgA Adhesin Retain the Same Function and Elicit Cross-Protection In Vivo

Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists...

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主要な著者: Moschioni, Monica, Emolo, Carla, Biagini, Massimiliano, Maccari, Silvia, Pansegrau, Werner, Donati, Claudio, Hilleringmann, Markus, Ferlenghi, Ilaria, Ruggiero, Paolo, Sinisi, Antonia, Pizza, Mariagrazia, Norais, Nathalie, Barocchi, Michèle A., Masignani, Vega
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
Molecular Pathogenesis
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981310/
https://ncbi.nlm.nih.gov/pubmed/20823200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00601-10
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