The Two Variants of the Streptococcus pneumoniae Pilus 1 RrgA Adhesin Retain the Same Function and Elicit Cross-Protection In Vivo

Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists...

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Detalhes bibliográficos
Main Authors: Moschioni, Monica, Emolo, Carla, Biagini, Massimiliano, Maccari, Silvia, Pansegrau, Werner, Donati, Claudio, Hilleringmann, Markus, Ferlenghi, Ilaria, Ruggiero, Paolo, Sinisi, Antonia, Pizza, Mariagrazia, Norais, Nathalie, Barocchi, Michèle A., Masignani, Vega
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981310/
https://ncbi.nlm.nih.gov/pubmed/20823200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00601-10
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