Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA enhanced t...

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Main Authors: Orrskog, Sofia, Rounioja, Samuli, Spadafina, Tiziana, Gallotta, Marilena, Norman, Martin, Hentrich, Karina, Fälker, Stefan, Ygberg-Eriksson, Sofia, Hasenberg, Mike, Johansson, Björn, Uotila, Liisa M., Gahmberg, Carl G., Barocchi, Michèle, Gunzer, Matthias, Normark, Staffan, Henriques-Normark, Birgitta
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531807/
https://ncbi.nlm.nih.gov/pubmed/23269830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00535-12
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