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Selection of CD8(+)PD-1(+) lymphocytes in fresh human melanomas enriches for tumor-reactive T-cells
CD8(+) Tumor infiltrating lymphocyte (TIL) in human melanomas express high levels of PD-1 and are functionally impaired. However, adoptive cell therapy using in vitro-expanded TIL can be a highly effective therapy for patients with advanced melanoma. This discrepancy led us to further analyze the CD...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980947/ https://ncbi.nlm.nih.gov/pubmed/20948441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181fad2b0 |
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