Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells

In autosomal dominant polycystic kidney disease (ADPKD), aberrant proliferation of the renal epithelial cells is responsible for the formation of numerable fluid-filled cysts, massively enlarged kidneys, and progressive loss of renal function. cAMP agonists, including arginine vasopressin, accelerat...

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Bibliografiska uppgifter
Huvudupphovsmän: Yamaguchi, Tamio, Reif, Gail A., Calvet, James P., Wallace, Darren P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2010
Ämnen:
Editorial Focus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980397/
https://ncbi.nlm.nih.gov/pubmed/20810616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00387.2010
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