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Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

Several lines of evidence suggest that erythroid-specific DNase I hypersensitive sites (HS) located far upstream of the human beta-globin gene are important in regulating beta-globin gene expression. We used the polymerase chain reaction technique to amplify and clone an 882-base-pair DNA fragment s...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Curtin, P T, Liu, D P, Liu, W, Chang, J C, Kan, Y W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297998/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2780563/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.18.7082
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