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Alta-Cyclic: a self-optimizing base caller for next-generation sequencing
Next-generation sequencing is limited to short read lengths and by high error rates. We systematically analyzed sources of noise in the Illumina Genome Analyzer that contribute to these high error rates and developed a base caller, Alta-Cyclic, that uses machine learning to compensate for noise fact...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978646/ https://ncbi.nlm.nih.gov/pubmed/18604217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1230 |
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