Polymorphic C-terminal β-Sheet Interactions Determine the Formation of Fibril or Amyloid β-derived Diffusible Ligand-like Globulomer for the Alzheimer Aβ42 Dodecamer

The relationship between amyloid deposition and cellular toxicity is still controversial. In addition to fibril-forming oligomers, other soluble Aβ forms (amyloid β-derived diffusible ligands (ADDLs)) were also suggested to form and to present different morphologies and mechanisms of toxicity. One A...

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Detaylı Bibliyografya
Asıl Yazarlar: Ma, Buyong, Nussinov, Ruth
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978638/
https://ncbi.nlm.nih.gov/pubmed/20847046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133488
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