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Calcium Inhibits Paracellular Sodium Conductance through Claudin-2 by Competitive Binding

Claudins form paracellular pores at the tight junction in epithelial cells. Profound depletion of extracellular calcium is well known to cause loosening of the tight junction with loss of transepithelial resistance. However, moderate variations in calcium concentrations within the physiological rang...

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Main Authors: Yu, Alan S. L., Cheng, Mary H., Coalson, Rob D.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978634/
https://ncbi.nlm.nih.gov/pubmed/20807759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146621
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