SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature aging. To investigate mechanisms underlying the pleiotropic phenoty...

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Autores principales: Xiao, Cuiying, Kim, Hyun-Seok, Lahusen, Tyler, Wang, Rui-Hong, Xu, Xiaoling, Gavrilova, Oksana, Jou, William, Gius, David, Deng, Chu-Xia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978606/
https://ncbi.nlm.nih.gov/pubmed/20847051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168039
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