Secretion of the Human Toll-like Receptor 3 Ectodomain Is Affected by Single Nucleotide Polymorphisms and Regulated by Unc93b1

The innate immune receptor Toll-like receptor 3 (TLR3) can be present on the surface of the plasma membranes of cells and in endolysosomes. The Unc93b1 protein has been reported to facilitate localization of TLR7 and 9 and is required for TLR3, -7, and -9 signaling. We demonstrate that siRNA knockdo...

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Autors principals: Qi, Rongsu, Hoose, Scott, Schreiter, Jessica, Sawant, Kirti V., Lamb, Roberta, Ranjith-Kumar, C. T., Mills, Juliane, Mateo, Lani San, Jordan, Jarrat L., Kao, C. Cheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978592/
https://ncbi.nlm.nih.gov/pubmed/20855885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144402
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