Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model

Mitomycin C induces both MC-mono-dG and cross-linked dG-adducts in vivo. Interstrand cross-linked (ICL) dG-MC-dG-DNA adducts can prevent strand separation. In Escherichia coli cells, UvrABC repairs ICL lesions that cause DNA bending. The mechanisms and consequences of NER of ICL dG-MC-dG lesions tha...

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Autors principals: Weng, Mao-wen, Zheng, Yi, Jasti, Vijay P., Champeil, Elise, Tomasz, Maria, Wang, Yinsheng, Basu, Ashis K., Tang, Moon-shong
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978355/
https://ncbi.nlm.nih.gov/pubmed/20647419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq576
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