Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin

The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)–based combination therapies for malaria, including mefloquine (MFQ)–artesunate and lumefantrine (LUM)–artemether. Clinical studies have identified an association between an inc...

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Detalhes bibliográficos
Main Authors: Sidhu, Amar Bir Singh, Uhlemann, Anne-Catrin, Valderramos, Stephanie G., Valderramos, Juan-Carlos, Krishna, Sanjeev, Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978021/
https://ncbi.nlm.nih.gov/pubmed/16845638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/507115
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