Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library.

Efficient generation of catalytic antibodies is uniquely dependent on the exact nature of the binding interactions in the antigen-antibody complex. Current methods for generation of monoclonal antibodies do not efficiently survey the immunological repertoire and, therefore, they limit the number of...

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Autores principales: Sastry, L, Alting-Mees, M, Huse, W D, Short, J M, Sorge, J A, Hay, B N, Janda, K D, Benkovic, S J, Lerner, R A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC297703/
https://ncbi.nlm.nih.gov/pubmed/2503822
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