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Hydroxypropyl Methylcellulose Acetate Succinate: Potential Drug–Excipient Incompatibility

The stability of hydroxypropyl methylcellulose acetate succinate (HPMC-AS) and its potential incompatibility with active pharmaceutical ingredients (API) carrying hydroxyl group(s) were investigated in this research. HPMC-AS may undergo hydrolysis under harsh processing conditions with the generatio...

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Библиографические подробности
Главные авторы: Dong, Zedong, Choi, Duk Soon
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977018/
https://ncbi.nlm.nih.gov/pubmed/18758966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-008-9138-5
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