Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in passive compared to active smokers

OBJECTIVES: Cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are widely used biomarkers for tobacco-derived nicotine and the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), respectively. The discrepancy between cotinine levels in relation to disease risk compar...

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Detalhes bibliográficos
Main Authors: Benowitz, Neal, Goniewicz, Maciej Lukasz, Eisner, Mark D., Lazcano-Ponce, Eduardo, Zielinska-Danch, Wioleta, Koszowski, Bartosz, Sobczak, Andrzej, Havel, Christopher, Jacob, Peyton
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976834/
https://ncbi.nlm.nih.gov/pubmed/20805316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-10-0497
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