Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families

BACKGROUND: Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so far involves minor alterations scattered throughout their coding regions as...

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Detalhes bibliográficos
Main Authors: Thodi, Georgia, Fostira, Florentia, Sandaltzopoulos, Raphael, Nasioulas, George, Grivas, Anastasios, Boukovinas, Ioannis, Mylonaki, Maria, Panopoulos, Christos, Magic, Mirjana Brankovic, Fountzilas, George, Yannoukakos, Drakoulis
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976752/
https://ncbi.nlm.nih.gov/pubmed/20937110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-544
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