Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

Activation of toll-like receptors (TLRs) on cells of the innate immune system initiates, amplifies, and directs the antigen-specific acquired immune response. Ligands that stimulate TLRs, therefore, represent potential immune adjuvants. In this study, a potent TLR7 agonist was conjugated to phosphol...

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Autors principals: Chan, Michael, Hayashi, Tomoko, Kuy, Crystal S., Gray, Christine S., Wu, Christina C. N., Corr, Maripat, Wrasidlo, Wolfgang, Cottam, Howard B., Carson, Dennis A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2009
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976567/
https://ncbi.nlm.nih.gov/pubmed/19445505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900054q
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