Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand

The immunotherapeutic activity of Toll-like receptor (TLR) activators has been difficult to exploit because of side effects related to the release and systemic dispersion of proinflammatory cytokines. To overcome this barrier, we have synthesized a versatile TLR7 agonist, 4-[6-amino-8-hydroxy-2-(2-m...

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Bibliographic Details
Main Authors: Wu, Christina C. N., Hayashi, Tomoko, Takabayashi, Kenji, Sabet, Mojgan, Smee, Donald F., Guiney, Donald D., Cottam, Howard B., Carson, Dennis A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820696/
https://ncbi.nlm.nih.gov/pubmed/17360465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611624104
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