Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies

Oncogenic transformation by adenovirus E1A and E1B-55K requires E1B-55K inhibition of p53 activity to prevent E1A-induced apoptosis. During viral infection, E1B-55K and E4orf6 substitute for the substrate-binding subunits of the host cell cullin 5 class of ubiquitin ligases, resulting in p53 polyubi...

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Bibliografiska uppgifter
Huvudupphovsmän: Pennella, Mario A., Liu, Yue, Woo, Jennifer L., Kim, Chongwoo A., Berk, Arnold J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
Ämnen:
Transformation and Oncogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976411/
https://ncbi.nlm.nih.gov/pubmed/20861261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01442-10
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