Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease

BI 201335 is a hepatitis C virus (HCV) NS3-NS4A (NS3 coexpressed with NS4A) protease inhibitor that has been shown to have potent clinical antiviral activity. It is a highly optimized noncovalent competitive inhibitor of full-length NS3-NS4A proteases of HCV genotypes 1a and 1b with K(i) values of 2...

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Autori principali: White, Peter W., Llinàs-Brunet, Montse, Amad, Ma'an, Bethell, Richard C., Bolger, Gordon, Cordingley, Michael G., Duan, Jianmin, Garneau, Michel, Lagacé, Lisette, Thibeault, Diane, Kukolj, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976164/
https://ncbi.nlm.nih.gov/pubmed/20823284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00787-10
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