Pharmacokinetics and Pharmacogenomics of Once-Daily Raltegravir and Atazanavir in Healthy Volunteers

Atazanavir inhibits UDP-glucuronyl-transferase-1A1 (UGT1A1), which metabolizes raltegravir, but the magnitude of steady-state inhibition and role of the UGT1A1 genotype are unknown. Sufficient inhibition could lead to reduced-dose and -cost raltegravir regimens. Nineteen healthy volunteers, age 24 t...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Neely, Michael, Decosterd, Laurent, Fayet, Aurélie, Lee, Janice Soo Fern, Margol, Ashley, Kanani, Meera, di Iulio, Julia, von Schoen-Angerer, Tido, Jelliffe, Roger, Calmy, Alexandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2010
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976128/
https://ncbi.nlm.nih.gov/pubmed/20823282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00712-10
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items