Pharmacokinetics and Pharmacogenomics of Once-Daily Raltegravir and Atazanavir in Healthy Volunteers

Atazanavir inhibits UDP-glucuronyl-transferase-1A1 (UGT1A1), which metabolizes raltegravir, but the magnitude of steady-state inhibition and role of the UGT1A1 genotype are unknown. Sufficient inhibition could lead to reduced-dose and -cost raltegravir regimens. Nineteen healthy volunteers, age 24 t...

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Autori principali: Neely, Michael, Decosterd, Laurent, Fayet, Aurélie, Lee, Janice Soo Fern, Margol, Ashley, Kanani, Meera, di Iulio, Julia, von Schoen-Angerer, Tido, Jelliffe, Roger, Calmy, Alexandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976128/
https://ncbi.nlm.nih.gov/pubmed/20823282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00712-10
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