Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. We have developed a poly(U) mRNA-directed aminoacylation/translation protein synthesis system composed of phenyl-tRNA synthetases, ribosomes, and ribosomal factors from Escherichia coli. This system, u...

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Main Authors: Ribble, Wendy, Hill, Walter E., Ochsner, Urs A., Jarvis, Thale C., Guiles, Joseph W., Janjic, Nebojsa, Bullard, James M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976125/
https://ncbi.nlm.nih.gov/pubmed/20696870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00638-10
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