Mode of Action and Biochemical Characterization of REP8839, a Novel Inhibitor of Methionyl-tRNA Synthetase

Aminoacyl-tRNA synthetases have attracted interest as essential and novel targets involved in bacterial protein synthesis. REP8839 is a potent inhibitor of MetS, the methionyl-tRNA synthetase in Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and in Streptococcus pyogenes. T...

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Main Authors: Ochsner, Urs A., Young, Casey L., Stone, Kimberley C., Dean, Frank B., Janjic, Nebojsa, Critchley, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251548/
https://ncbi.nlm.nih.gov/pubmed/16189106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.10.4253-4262.2005
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