Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

QPT-1 was discovered in a compound library by high-throughput screening and triage for substances with whole-cell antibacterial activity. This totally synthetic compound is an unusual barbituric acid derivative whose activity resides in the (−)-enantiomer. QPT-1 had activity against a broad spectrum...

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Autors principals: Miller, Alita A., Bundy, Gordon L., Mott, John E., Skepner, Jill E., Boyle, Timothy P., Harris, Douglas W., Hromockyj, Alexander E., Marotti, Keith R., Zurenko, Gary E., Munzner, Jennifer B., Sweeney, Michael T., Bammert, Gary F., Hamel, Judith C., Ford, Charles W., Zhong, Wei-Zhu, Graber, David R., Martin, Gary E., Han, Fusen, Dolak, Lester A., Seest, Eric P., Ruble, J. Craig, Kamilar, Gregg M., Palmer, John R., Banitt, Lee S., Hurd, Alexander R., Barbachyn, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493097/
https://ncbi.nlm.nih.gov/pubmed/18519725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00247-08
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