Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

QPT-1 was discovered in a compound library by high-throughput screening and triage for substances with whole-cell antibacterial activity. This totally synthetic compound is an unusual barbituric acid derivative whose activity resides in the (−)-enantiomer. QPT-1 had activity against a broad spectrum...

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Detalhes bibliográficos
Main Authors: Miller, Alita A., Bundy, Gordon L., Mott, John E., Skepner, Jill E., Boyle, Timothy P., Harris, Douglas W., Hromockyj, Alexander E., Marotti, Keith R., Zurenko, Gary E., Munzner, Jennifer B., Sweeney, Michael T., Bammert, Gary F., Hamel, Judith C., Ford, Charles W., Zhong, Wei-Zhu, Graber, David R., Martin, Gary E., Han, Fusen, Dolak, Lester A., Seest, Eric P., Ruble, J. Craig, Kamilar, Gregg M., Palmer, John R., Banitt, Lee S., Hurd, Alexander R., Barbachyn, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493097/
https://ncbi.nlm.nih.gov/pubmed/18519725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00247-08
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