Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

QPT-1 was discovered in a compound library by high-throughput screening and triage for substances with whole-cell antibacterial activity. This totally synthetic compound is an unusual barbituric acid derivative whose activity resides in the (−)-enantiomer. QPT-1 had activity against a broad spectrum...

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Detaylı Bibliyografya
Asıl Yazarlar: Miller, Alita A., Bundy, Gordon L., Mott, John E., Skepner, Jill E., Boyle, Timothy P., Harris, Douglas W., Hromockyj, Alexander E., Marotti, Keith R., Zurenko, Gary E., Munzner, Jennifer B., Sweeney, Michael T., Bammert, Gary F., Hamel, Judith C., Ford, Charles W., Zhong, Wei-Zhu, Graber, David R., Martin, Gary E., Han, Fusen, Dolak, Lester A., Seest, Eric P., Ruble, J. Craig, Kamilar, Gregg M., Palmer, John R., Banitt, Lee S., Hurd, Alexander R., Barbachyn, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493097/
https://ncbi.nlm.nih.gov/pubmed/18519725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00247-08
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