Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

Overexpression of alpha-synuclein (α-SYN), a protein which plays an important role in the pathogenesis of Parkinson's disease (PD), triggers microglial activation and adaptive immune responses, and leads to neurodegeneration of dopaminergic (DA) neurons. We hypothesized a link between the humor...

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Bibliographic Details
Main Authors: Cao, Shuwen, Theodore, Shaji, Standaert, David G
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975641/
https://ncbi.nlm.nih.gov/pubmed/20977765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-42
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