MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

Accumulation of α-synuclein (α-syn) in the brain is a core feature of Parkinson disease (PD) and leads to microglial activation, production of inflammatory cytokines and chemokines, T-cell infiltration, and neurodegeneration. Here, we have used both an in vivo mouse model induced by viral overexpres...

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Detalhes bibliográficos
Main Authors: Harms, Ashley S., Cao, Shuwen, Rowse, Amber L., Thome, Aaron D., Li, Xinru, Mangieri, Leandra R., Cron, Randy Q., Shacka, John J., Raman, Chander, Standaert, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903980/
https://ncbi.nlm.nih.gov/pubmed/23739956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5610-12.2013
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