Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the innate and adaptive immune systems. Disruption of immune signaling between the cent...

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Foilsithe in:J Neuroinflammation
Main Authors: Williams, Gregory P., Schonhoff, Aubrey M., Jurkuvenaite, Asta, Thome, Aaron D., Standaert, David G., Harms, Ashley S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117927/
https://ncbi.nlm.nih.gov/pubmed/30165873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1286-2
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