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Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step

The generation of reactive oxygen species in the cell provokes, among other lesions, the formation of 8-oxo-7,8-dihydroguanine (8-oxoG) in DNA. Due to mispairing with adenine during replication, 8-oxoG is highly mutagenic. To minimise the mutagenic potential of this oxidised purine, human cells have...

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Bibliografische gegevens
Hoofdauteurs: Vidal, Antonio E., Hickson, Ian D., Boiteux, Serge, Radicella, J. Pablo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC29755/
https://ncbi.nlm.nih.gov/pubmed/11238994
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